Pre_GI Gene

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Host: NC_017160 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_017160:905783 Yersinia pestis D182038 chromosome, complete genome

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
904849905799951putative siderophore biosynthesis protein IucBQuickGO ontologyBLASTP
9057839068531071aerobactin synthetase subunit alphaQuickGO ontologyBLASTP
906946907554609aerobactin synthetase subunit alphaQuickGO ontologyBLASTP
9076949089171224hypothetical proteinBLASTP
909207910040834hypothetical proteinBLASTP
9104179117931377hypothetical proteinBLASTP
912355913098744quorum-sensing transcriptional regulatorQuickGO ontologyBLASTP
913079913606528N-acylhomoserine lactone synthase YtbIQuickGO ontologyBLASTP
915132915554423CAAX amino terminal protease family proteinQuickGO ontologyBLASTP
918676919176501hypothetical proteinBLASTP
9192259207631539hypothetical proteinBLASTP
9208809221271248hypothetical proteinBLASTP
922124922810687hypothetical proteinBLASTP
9228109245461737hypothetical proteinBLASTP