Pre_GI Gene

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Host: NC_017160 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_017160:737000 Yersinia pestis D182038 chromosome, complete genome

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
737054737947894AraC-family regulatory proteinQuickGO ontologyBLASTP
738039738701663putative DedA-family membrane proteinQuickGO ontologyBLASTP
7388947401051212cystathionine beta-lyaseQuickGO ontologyBLASTP
7405847416211038MotATolQExbB proton channel family proteinQuickGO ontologyBLASTP
741625742056432ExbDTolR-family transport proteinQuickGO ontologyBLASTP
7421537437091557hypothetical proteinBLASTP
743734744306573hypothetical proteinBLASTP
744290744760471hypothetical proteinBLASTP
744760745530771hypothetical proteinBLASTP
745514746347834hypothetical proteinBLASTP
746344747219876hypothetical proteinBLASTP
7472167485021287putative type II secretion proteinQuickGO ontologyBLASTP
7485147496411128hypothetical proteinBLASTP
749939750388450hypothetical proteinBLASTP
750403751257855hypothetical proteinBLASTP
751254752120867hypothetical proteinBLASTP
752172752594423hypothetical proteinBLASTP
752743753132390IS1541 transposaseQuickGO ontologyBLASTP
753454753963510transposaseQuickGO ontologyBLASTP
7543167567962481outer membrane usher proteinQuickGO ontologyBLASTP
756814757533720fimbrial chaperone proteinQuickGO ontologyBLASTP
7575587586641107Fimbrial proteinQuickGO ontologyBLASTP
7588767599551080ferric enterobactin enterochelin binding proteinQuickGO ontologyBLASTP
760811761806996hypothetical proteinBLASTP