Pre_GI Gene

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Host: NC_017160 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_017160:676249 Yersinia pestis D182038 chromosome, complete genome

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
6762496776101362outer membrane efflux proteinQuickGO ontologyBLASTP
6777796796801902hypothetical proteinBLASTP
6796646807131050putative HlyD family secretion proteinQuickGO ontologyBLASTP
6820216832531233putative aminotransferaseQuickGO ontologyBLASTP
6832856846971413NaH antiporter family proteinQuickGO ontologyBLASTP
684710685147438hypothetical proteinBLASTP
685281685907627hypothetical proteinBLASTP
685923686303381putative translational inhibitor proteinQuickGO ontologyBLASTP
686588686992405putative translational inhibitor proteinQuickGO ontologyBLASTP
687207687509303hypothetical proteinBLASTP
687769688485717hypothetical proteinBLASTP
688665689579915LysR-family regulatory proteinQuickGO ontologyBLASTP
691615692211597hypothetical proteinBLASTP
692288692602315hypothetical proteinBLASTP
693008693478471hypothetical proteinBLASTP
693505693960456hypothetical proteinBLASTP
6950996961571059RNA polymerase sigma factor RpoDQuickGO ontologyBLASTP