Pre_GI Gene

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Host: NC_017160 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_017160:520799 Yersinia pestis D182038 chromosome, complete genome

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
520799521617819dimethyladenosine transferaseQuickGO ontologyBLASTP
5216105226059964-hydroxythreonine-4-phosphate dehydrogenaseQuickGO ontologyBLASTP
5225895238931305survival protein SurA peptidyl-prolyl cis-trans isomeraseQuickGO ontologyBLASTP
5239615262132253organic solvent tolerance proteinQuickGO ontologyBLASTP
526488527321834Dna-J like membrane chaperone proteinQuickGO ontologyBLASTP
527619528239621ribosomal large subunit pseudouridine synthase AQuickGO ontologyBLASTP
529462530205744hypothetical proteinBLASTP
5305355315481014hypothetical proteinBLASTP
531559532119561hypothetical proteinBLASTP
5321195336301512hypothetical proteinBLASTP
533793534311519hypothetical proteinBLASTP
534385534828444hypothetical proteinBLASTP
5348615367051845hypothetical proteinBLASTP
536698537681984hypothetical proteinBLASTP
5376995402872589Clp ATPaseQuickGO ontologyBLASTP