Pre_GI Gene

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Host: NC_017160 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_017160:479411 Yersinia pestis D182038 chromosome, complete genome

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
479411480127717aerobic respiration control proteinQuickGO ontologyBLASTP
4812314836902460bifunctional aspartokinasehomoserine dehydrogenase IQuickGO ontologyBLASTP
483693484622930homoserine kinaseQuickGO ontologyBLASTP
4846264859151290threonine synthaseQuickGO ontologyBLASTP
486732487508777hypothetical proteinBLASTP
488039488992954transaldolaseQuickGO ontologyBLASTP
489280489867588molybdenum cofactor biosynthesis proteinQuickGO ontologyBLASTP
4899954913831389putative transport proteinQuickGO ontologyBLASTP
4914534939002448hypothetical proteinBLASTP
494189494800612hypothetical proteinBLASTP
4951744970841911molecular chaperone DnaKQuickGO ontologyBLASTP
4971964983351140chaperone protein DnaJQuickGO ontologyBLASTP
4985784997621185sodium-proton antiporterQuickGO ontologyBLASTP
499892500791900transcriptional activator protein NhaRQuickGO ontologyBLASTP
501651502211561bifunctional riboflavin kinaseFMN adenylyltransferaseQuickGO ontologyBLASTP