Pre_GI Gene

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Host: NC_017160 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_017160:4073611 Yersinia pestis D182038 chromosome, complete genome

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
407361140747411131putative oxidoreductaseQuickGO ontologyBLASTP
40747384075637900hypothetical proteinBLASTP
40759844076778795hypothetical proteinBLASTP
407678740813254539hypothetical proteinBLASTP
40813704081741372hypothetical proteinBLASTP
408179540839932199putative Rhs accessory genetic elementQuickGO ontologyBLASTP
40843544084761408transcriptional regulatorQuickGO ontologyBLASTP
40853844085869486hypothetical proteinBLASTP
408587140872411371hypothetical proteinBLASTP
408726940901332865hypothetical proteinBLASTP
40901264090584459hypothetical proteinBLASTP
409059040929922403putative Rhs accessory genetic elementQuickGO ontologyBLASTP