Pre_GI Gene

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Host: NC_017160 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_017160:3986844 Yersinia pestis D182038 chromosome, complete genome

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
39865093986847339hypothetical proteinBLASTP
398684439879771134succinate-semialdehyde dehydrogenaseQuickGO ontologyBLASTP
398824439901991956membrane proteinQuickGO ontologyBLASTP
39902013991136936putative HlyD family secretion proteinQuickGO ontologyBLASTP
39916503992561912LysR family transcriptional regulatorQuickGO ontologyBLASTP
39928763993688813lysR-family transcriptional regulatory proteinQuickGO ontologyBLASTP
399392439964252502putative insecticidal toxinQuickGO ontologyBLASTP
399646639978481383toxin subunitQuickGO ontologyBLASTP
399791740000582142toxin subunitQuickGO ontologyBLASTP
400011540046054491insecticidal toxin complexQuickGO ontologyBLASTP
40050544005455402putative phage-like proteinQuickGO ontologyBLASTP
40054434005811369hypothetical proteinBLASTP
400601240088432832toxin subunitQuickGO ontologyBLASTP