Pre_GI Gene

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Host: NC_017160 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_017160:396600 Yersinia pestis D182038 chromosome, complete genome

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
3966003982431644putative acyl-CoA dehydrogenaseQuickGO ontologyBLASTP
398966399745780insertion sequence IS100 ATP-binding proteinQuickGO ontologyBLASTP
3997454007671023transposase for insertion sequence IS100QuickGO ontologyBLASTP
4009014029642064hypothetical proteinBLASTP
4029614042771317hypothetical proteinBLASTP
4053014066261326modification methylaseQuickGO ontologyBLASTP
406676407398723hypothetical proteinBLASTP
4073704087431374hypothetical proteinBLASTP
4100154114031389hypothetical proteinBLASTP
4114004125541155hypothetical proteinBLASTP
4127004137461047M48 peptidase family proteinQuickGO ontologyBLASTP
4137574149531197hypothetical proteinBLASTP
415659416195537hypothetical proteinBLASTP
416197417072876putative transcriptional regulatorQuickGO ontologyBLASTP
417065417409345PTS system transporter subunit IIBQuickGO ontologyBLASTP
417502417822321PTS system transporter subunit IIBQuickGO ontologyBLASTP
4181634192451083PTS system transporter subunit IICQuickGO ontologyBLASTP
4197394221682430HPr family phosphocarrier proteinQuickGO ontologyBLASTP