Pre_GI Gene

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Host: NC_017160 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_017160:3560153 Yersinia pestis D182038 chromosome, complete genome

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
35601533560911759hypothetical proteinBLASTP
356123935624981260gamma-glutamyl phosphate reductaseQuickGO ontologyBLASTP
356250835636111104gamma-glutamyl kinaseQuickGO ontologyBLASTP
35637883564189402curlin genes regulatory proteinQuickGO ontologyBLASTP
356424935654961248hypothetical proteinBLASTP
35656233566081459xanthine phosphoribosyltransferaseQuickGO ontologyBLASTP
356701035686141605carbohydrate-binding proteinQuickGO ontologyBLASTP
35690743569859786LysR-family transcriptional regulatory proteinQuickGO ontologyBLASTP
357186035733201461aminoacyl-histidine dipeptidaseQuickGO ontologyBLASTP
357343435744921059DNA polymerase IVQuickGO ontologyBLASTP
35748483575795948hypothetical proteinBLASTP
35762793577274996putative thiamine biosynthesis lipoprotein apbEQuickGO ontologyBLASTP
357734235785651224Na-translocating NADH-quinone reductase subunit FQuickGO ontologyBLASTP
35785813579177597Na-translocating NADH-quinone reductase subunit EQuickGO ontologyBLASTP
35791843579813630NADH-ubiquinone oxidoreductaseQuickGO ontologyBLASTP
35798063580606801Na-translocating NADH-quinone reductase subunit CQuickGO ontologyBLASTP
358059635818371242Na-translocating NADH-quinone reductase subunit BQuickGO ontologyBLASTP
358184135831841344Na-translocating NADH-quinone reductase subunit AQuickGO ontologyBLASTP