Pre_GI Gene

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Host: NC_017160 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_017160:3426486 Yersinia pestis D182038 chromosome, complete genome

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
34264863427109624hypothetical proteinBLASTP
34271033427894792UDP-sugar hydrolaseQuickGO ontologyBLASTP
342842334296371215putative membrane efflux proteinQuickGO ontologyBLASTP
342987234315601689potassium antiporterQuickGO ontologyBLASTP
343165734328891233inosine-guanosine kinaseQuickGO ontologyBLASTP
34331653434016852O-antigen chain length determinantQuickGO ontologyBLASTP
343436434357371374phosphomannomutaseQuickGO ontologyBLASTP
34357423436485744glycosyl transferaseQuickGO ontologyBLASTP
343648834378941407mannose-1-phosphate guanylyltransferaseQuickGO ontologyBLASTP
34381443439109966nucleotide di-P-sugar epimerase or dehydrataseQuickGO ontologyBLASTP
34391153439708594GDP-mannose 46-dehydrataseQuickGO ontologyBLASTP
34397193440237519hypothetical proteinBLASTP
344025334412661014putative mannosyltransferaseQuickGO ontologyBLASTP
34415153442411897O-unit polymerase-like proteinQuickGO ontologyBLASTP
344273334438751143putative mannosyltransferaseQuickGO ontologyBLASTP