Pre_GI Gene

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Host: NC_017160 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_017160:3326199 Yersinia pestis D182038 chromosome, complete genome

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
332619933275481350putative two-component system sensor kinaseQuickGO ontologyBLASTP
33275743328257684putative two-component system response regulatorQuickGO ontologyBLASTP
332844533296501206putative HlyD family secretion proteinQuickGO ontologyBLASTP
332965433316902037ABC transporter ATP-binding proteinQuickGO ontologyBLASTP
333194533335911647putative pyridine nucleotide-disulfide oxidoreductaseQuickGO ontologyBLASTP
333365133351111461putative permeaseQuickGO ontologyBLASTP
333544833364551008peptidaseQuickGO ontologyBLASTP
333670133378821182putative aminotransferaseQuickGO ontologyBLASTP
333859033400081419membrane proteinQuickGO ontologyBLASTP
334022933417851557two-component sensor histidine kinaseQuickGO ontologyBLASTP
33417823342489708response regulatorQuickGO ontologyBLASTP
334287033441021233hypothetical proteinBLASTP
33443473345225879cysteine synthase BQuickGO ontologyBLASTP
334539633464871092sulfate transport ATP-binding proteinQuickGO ontologyBLASTP
33464773347352876sulfate transport system permease CysWQuickGO ontologyBLASTP
33473523348185834sulfate transport system permease CysTQuickGO ontologyBLASTP
334818533492221038thiosulfate-binding proteinQuickGO ontologyBLASTP