Pre_GI Gene

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Host: NC_017160 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_017160:3094768 Yersinia pestis D182038 chromosome, complete genome

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
309476830962551488GTP-binding protein EngAQuickGO ontologyBLASTP
30966023097558957hypothetical proteinBLASTP
309792430993031380exodeoxyribonuclease VII large subunitQuickGO ontologyBLASTP
309938931009361548inositol-5-monophosphate dehydrogenaseQuickGO ontologyBLASTP
310111631026931578bifunctional GMP synthaseglutamine amidotransferase proteinQuickGO ontologyBLASTP
31030173103526510transposaseQuickGO ontologyBLASTP
31036863104165480hypothetical proteinBLASTP
31059593106594636hypothetical proteinBLASTP
310668531078931209transposase for the IS285 insertion elementQuickGO ontologyBLASTP
31082423108709468membrane proteinQuickGO ontologyBLASTP
31092313110031801phosphomethylpyrimidine kinaseQuickGO ontologyBLASTP
31100933110839747hypothetical proteinBLASTP
31112123111721510hypothetical proteinBLASTP
31119883112878891putative diacylglycerol kinaseQuickGO ontologyBLASTP
311351431148331320proteaseQuickGO ontologyBLASTP