Pre_GI Gene

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Host: NC_017160 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_017160:2976683 Yersinia pestis D182038 chromosome, complete genome

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
29760242976686663urease accessory proteinQuickGO ontologyBLASTP
29766832977516834hypothetical proteinBLASTP
29778412978833993putative urea transporterQuickGO ontologyBLASTP
297898229800401059putative nickel transport proteinQuickGO ontologyBLASTP
29802092980538330hypothetical proteinBLASTP
298115629823311176putative potassium channel proteinQuickGO ontologyBLASTP
29824292982833405camphor resistance protein CrcBQuickGO ontologyBLASTP
29828492983211363membrane proteinQuickGO ontologyBLASTP
29842712984588318PTS system cellobiose-specific transporter subunit IIBQuickGO ontologyBLASTP
298459929859601362PTS system cellobiose-specific transporter subunit IICQuickGO ontologyBLASTP
29861272986474348PTS system cellobiose-specific transporter subunit IIAQuickGO ontologyBLASTP
29865232987353831cel operon repressorQuickGO ontologyBLASTP
29874052988166762hypothetical proteinBLASTP
29893242989851528putative negative regulator of replication initiationQuickGO ontologyBLASTP
298992429915671644phosphoglucomutaseQuickGO ontologyBLASTP
29923112992739429hypothetical proteinBLASTP
29928342993463630two-component regulatory protein response regulator KdpEQuickGO ontologyBLASTP
299375629961582403sensor protein KdpDQuickGO ontologyBLASTP