Pre_GI Gene

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Host: NC_017160 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_017160:2787637 Yersinia pestis D182038 chromosome, complete genome

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
278763727887641128hypothetical proteinBLASTP
27890842789587504DNA protection proteinQuickGO ontologyBLASTP
27898442790620777trans-aconitate 2-methyltransferaseQuickGO ontologyBLASTP
27906432791140498hypothetical proteinBLASTP
27911562792043888hypothetical proteinBLASTP
27924482792972525outer membrane protein XQuickGO ontologyBLASTP
27932882794226939hypothetical proteinBLASTP
27944642795006543hypothetical proteinBLASTP
27952022795870669hypothetical proteinBLASTP
279645327976791227putative zinc-binding dehydrogenaseQuickGO ontologyBLASTP
27978542798477624sugar binding proteinQuickGO ontologyBLASTP
27984582798772315sugar binding proteinQuickGO ontologyBLASTP
279881228003021491putative sugar transport system ATP-binding proteinQuickGO ontologyBLASTP
28002992801291993putative sugar transport system permeaseQuickGO ontologyBLASTP
280142428024281005putative LacI-family transcriptional regulatorQuickGO ontologyBLASTP
28026752803616942putative LlysR-family transcriptional regulatory proteinQuickGO ontologyBLASTP
280371928048041086tartrate dehydrogenaseQuickGO ontologyBLASTP
280542128070671647putative BCCT-family transporterQuickGO ontologyBLASTP
280718428083081125putative dioxygenase subunit alphaQuickGO ontologyBLASTP
28084192809369951oxidoreductase FADNAD binding2Fe-2S iron-sulfur cluster binding domain-containing proteinQuickGO ontologyBLASTP
281002228117101689putative hemolysin activator proteinQuickGO ontologyBLASTP
28194502819959510hypothetical proteinBLASTP
282111928226901572hemagglutinin-like secreted proteinQuickGO ontologyBLASTP
28244362824828393hypothetical proteinBLASTP
28251792825631453hypothetical proteinBLASTP
282589628269751080putative mannitol transport ATP-binding proteinQuickGO ontologyBLASTP
282707528284631389phosphomannomutaseQuickGO ontologyBLASTP