Pre_GI Gene

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Host: NC_017160 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_017160:2414000 Yersinia pestis D182038 chromosome, complete genome

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
241401524150911077hypothetical proteinBLASTP
24173372417642306hypothetical proteinBLASTP
24183172418736420hypothetical proteinBLASTP
24188082419767960putative transposaseQuickGO ontologyBLASTP
24230742423583510transposaseQuickGO ontologyBLASTP
2423743242382886tRNA-LeuQuickGO ontologyBLASTP
2423839242391274tRNA-CysQuickGO ontologyBLASTP
2423965242404076tRNA-GlyQuickGO ontology
24241852424733549CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferaseQuickGO ontologyBLASTP
24247922425529738excinuclease ABC subunit CQuickGO ontologyBLASTP
242552624265571032excinuclease ABC subunit CQuickGO ontologyBLASTP
24266162427272657response regulatorQuickGO ontologyBLASTP
24282842428628345hypothetical proteinBLASTP
24292502429801552attachment invasion locus proteinQuickGO ontologyBLASTP
2430488243056376tRNA-LysQuickGO ontologyBLASTP
243092524323401416D-serineD-alanineglycine transporterQuickGO ontologyBLASTP
243246624336441179hypothetical proteinBLASTP
24340382434637600TrpR binding protein WrbAQuickGO ontologyBLASTP
243472324360271305hypothetical proteinBLASTP
243603824371681131hypothetical proteinBLASTP