Pre_GI Gene

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Host: NC_017160 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_017160:2362002 Yersinia pestis D182038 chromosome, complete genome

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
236200223645662565fimbrial usher proteinQuickGO ontologyBLASTP
236465423659311278hypothetical proteinBLASTP
23659282366668741pili assembly chaperoneQuickGO ontologyBLASTP
2366971236704676tRNA-AsnQuickGO ontologyBLASTP
236720823684701263integraseQuickGO ontologyBLASTP
236866423699681305anthranilate synthase component IQuickGO ontologyBLASTP
236999623712761281putative signal transducerQuickGO ontologyBLASTP
237126923724231155inner membrane ABC-transporter YbtQQuickGO ontologyBLASTP
23724372373072636inner membrane ABC-transporter YbtQQuickGO ontologyBLASTP
237305923747711713lipoprotein inner membrane ABC-transporterQuickGO ontologyBLASTP
23750282375987960transcriptional regulator YbtAQuickGO ontologyBLASTP
237617823822856108yersiniabactin biosynthetic proteinQuickGO ontologyBLASTP
239186123929611101yersiniabactin biosynthetic protein YbtUQuickGO ontologyBLASTP
23930242393761738yersiniabactin biosynthetic protein YbtTQuickGO ontologyBLASTP
239376523953421578yersiniabactin siderophore biosynthetic proteinQuickGO ontologyBLASTP
239547323974942022pesticinyersiniabactin receptor proteinQuickGO ontologyBLASTP
23988602399294435yp42QuickGO ontologyBLASTP
23998082400389582hypothetical proteinBLASTP
24009882401722735insertion sequence IS100 ATP-binding proteinQuickGO ontologyBLASTP
240176624027881023transposase for insertion sequence IS100QuickGO ontologyBLASTP
24039282404818891putative binding-protein-dependent transport system ATP-binding componentQuickGO ontologyBLASTP