Pre_GI Gene

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Host: NC_017160 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_017160:2212806 Yersinia pestis D182038 chromosome, complete genome

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
22120062212809804hypothetical proteinBLASTP
22128062213777972hypothetical proteinBLASTP
22139702214734765putative copper homeostasis proteinQuickGO ontologyBLASTP
22149662215541576hypothetical proteinBLASTP
221618422179141731arginyl-tRNA synthetaseQuickGO ontologyBLASTP
221814522227554611hemolysinQuickGO ontologyBLASTP
222290522245661662putative hemolysin activator proteinQuickGO ontologyBLASTP
222504622265811536hypothetical proteinBLASTP
222684822284581611putative oxidoreductaseQuickGO ontologyBLASTP
22284662228858393ribosomal-protein-alanine acetyltransferaseQuickGO ontologyBLASTP
222934422305491206hypothetical proteinBLASTP
22309442231507564putative lipoproteinQuickGO ontologyBLASTP
22319612232521561hypothetical proteinBLASTP
22328022233296495hypothetical proteinBLASTP
2233585223367490tRNA-SerQuickGO ontologyBLASTP