Pre_GI Gene

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Host: NC_017160 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_017160:2054289 Yersinia pestis D182038 chromosome, complete genome

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
205428920554551167hypothetical proteinBLASTP
20555102056172663GTP cyclohydrolase IQuickGO ontologyBLASTP
205635620575071152hypothetical proteinBLASTP
20576432058512870putative LysR-family transcriptional regulatory proteinQuickGO ontologyBLASTP
205878620599251140alcohol dehydrogenaseQuickGO ontologyBLASTP
20599462060788843putative esteraseQuickGO ontologyBLASTP
206138320637012319hypothetical proteinBLASTP
206370320649651263hypothetical proteinBLASTP
20649672065635669ABC transporter ATP-binding proteinQuickGO ontologyBLASTP
206564520669551311putative heme-binding proteinQuickGO ontologyBLASTP
206749020687641275molybdopterin biosynthesis proteinQuickGO ontologyBLASTP
20687662069536771molybdopterin biosynthesis proteinQuickGO ontologyBLASTP
206967220708801209transposase for the IS285 insertion elementQuickGO ontologyBLASTP
20709162071674759TonB proteinQuickGO ontologyBLASTP
20733392073878540attachment invasion locus proteinQuickGO ontologyBLASTP
207492520763851461cardiolipin synthetaseQuickGO ontologyBLASTP
20765502076873324hypothetical proteinBLASTP
207794820789491002oligopeptide transport ATP-binding proteinQuickGO ontologyBLASTP
207894620799471002oligopeptide ABC transporter ATP-binding proteinQuickGO ontologyBLASTP
20799592080864906oligopeptide transport system permeaseQuickGO ontologyBLASTP
20808832081803921oligopeptide permease ABC transporter membrane proteinQuickGO ontologyBLASTP
208189020834671578oligopeptide ABC transporter periplasmic oligopeptide-binding proteinQuickGO ontologyBLASTP
20843652085009645hypothetical proteinBLASTP
208581620884912676aldehyde-alcohol dehydrogenaseQuickGO ontologyBLASTP
208903120900531023transposase for insertion sequence IS100QuickGO ontologyBLASTP
20900532090832780insertion sequence IS100 ATP-binding proteinQuickGO ontologyBLASTP
20912012091701501thymidine kinaseQuickGO ontologyBLASTP
20925412092939399DNA-binding protein HnsQuickGO ontologyBLASTP
209337420947201347putative nucleotide sugar dehydrogenaseQuickGO ontologyBLASTP