Pre_GI Gene

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Host: NC_017160 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_017160:1507500 Yersinia pestis D182038 chromosome, complete genome

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
150764315088991257citrate synthase GltAQuickGO ontologyBLASTP
15090321509610579heat shock protein GrpEQuickGO ontologyBLASTP
15097341510513780hypothetical proteinBLASTP
151070115123621662DNA repair protein RecNQuickGO ontologyBLASTP
15124761512817342hypothetical proteinBLASTP
15132441513678435hypothetical proteinBLASTP
15138391514321483SsrA-binding proteinQuickGO ontologyBLASTP
15149051515414510transposaseQuickGO ontologyBLASTP
151563815168371200putative prophage integraseQuickGO ontologyBLASTP
151691615180041089hypothetical proteinBLASTP
151805515197251671hypothetical proteinBLASTP
15209221521809888DNA-binding prophage proteinQuickGO ontologyBLASTP
15227411523496756putative prophage DNA primaseQuickGO ontologyBLASTP
152349315245811089putative regulatory prophage proteinQuickGO ontologyBLASTP
15249301525244315DNA-binding prophage proteinQuickGO ontologyBLASTP
152617215271941023transposase for insertion sequence IS100QuickGO ontologyBLASTP
15271941527973780insertion sequence IS100 ATP-binding proteinQuickGO ontologyBLASTP
15282081528816609putative prepilin peptidase dependent proteinQuickGO ontologyBLASTP
15288131529283471hypothetical proteinBLASTP
15292711529681411putative prepilin peptidase dependent proteinQuickGO ontologyBLASTP
152981615331873372exodeoxyribonuclease V subunit gammaQuickGO ontologyBLASTP