Pre_GI Gene

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Host: NC_017160 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_017160:1299733 Yersinia pestis D182038 chromosome, complete genome

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
129973313012411509PTS system fructose-specific transporter subunit IIBCQuickGO ontologyBLASTP
130125613021949391-phosphofructokinaseQuickGO ontologyBLASTP
130219113033241134hypothetical proteinBLASTP
13035861304041456Mut family proteinQuickGO ontologyBLASTP
13041541305152999putative ABC transport integral membrane subunitQuickGO ontologyBLASTP
130518813067621575putative ABC transport ATP-binding subunitQuickGO ontologyBLASTP
130687113079591089periplasmic carbohydrate-binding transport proteinQuickGO ontologyBLASTP
13080911308801711putative ribose 5-phosphate isomeraseQuickGO ontologyBLASTP
130882113103741554putative carbohydrate kinaseQuickGO ontologyBLASTP
131037813118741497putative aldehyde dehydrogenaseQuickGO ontologyBLASTP
13122261313062837hypothetical proteinBLASTP
13135211314330810D-isomer specific 2-hydroxyacid dehydrogenase family proteinQuickGO ontologyBLASTP
13143411315156816putative short chain oxidoreductaseQuickGO ontologyBLASTP
131585413170981245tyrosine-specific transport proteinQuickGO ontologyBLASTP
13171601317774615elongation factor PQuickGO ontologyBLASTP
131791413191071194mannonate dehydrataseQuickGO ontologyBLASTP
131969213208911200D-mannonate oxidoreductaseQuickGO ontologyBLASTP
13213071322050744transcriptional regulatorQuickGO ontologyBLASTP
13230481323842795cobalamin synthesis proteinQuickGO ontologyBLASTP