Pre_GI Gene

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Host: NC_017160 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_017160:1092839 Yersinia pestis D182038 chromosome, complete genome

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
109283910959133075hypothetical proteinBLASTP
10960221096414393hypothetical proteinBLASTP
109643110981341704hypothetical proteinBLASTP
10983251099275951hypothetical proteinBLASTP
11006401101317678putative carbonic anhydraseQuickGO ontologyBLASTP
11020601102476417hypothetical proteinBLASTP
11026461103047402general secretion pathway protein CQuickGO ontologyBLASTP
110312811050501923general secretion proteinQuickGO ontologyBLASTP
110504711065581512general secretion pathway protein EQuickGO ontologyBLASTP
110670011077461047general protein secretion proteinQuickGO ontologyBLASTP
11077661108203438general secretion pathway protein GQuickGO ontologyBLASTP
11091251109721597general secretion pathway protein JQuickGO ontologyBLASTP
11097901110686897general secretion pathway protein KQuickGO ontologyBLASTP
111067011118601191L-like GSP proteinQuickGO ontologyBLASTP
11118691112318450membrane proteinQuickGO ontologyBLASTP
11123471113186840prepilin peptidaseQuickGO ontologyBLASTP
11132381113543306putative lipoproteinQuickGO ontologyBLASTP
11138271114543717putative regulatory membrane proteinQuickGO ontologyBLASTP
111509611167871692methyl-accepting chemotaxis proteinQuickGO ontologyBLASTP
11167731117408636hypothetical proteinBLASTP
11175211118408888hypothetical proteinBLASTP
11185151119423909LysR-family transcriptional regulatory proteinQuickGO ontologyBLASTP
111979211209521161putative sugar transport proteinQuickGO ontologyBLASTP
11210651121889825transcriptional activator protein LysRQuickGO ontologyBLASTP
112210411233661263diaminopimelate decarboxylaseQuickGO ontologyBLASTP
112336311243851023galactose operon repressorQuickGO ontologyBLASTP