Pre_GI Gene

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Host: NC_017154 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_017154:941065 Yersinia pestis D106004 chromosome, complete genome

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
9410659430982034TonB-dependent siderophore receptorQuickGO ontologyBLASTP
9432029443021101hypothetical proteinBLASTP
9446029456781077membrane-bound lytic murein transglycosylase CQuickGO ontologyBLASTP
9463119474291119AG-specific adenine glycosylaseQuickGO ontologyBLASTP
947764948483720tRNA guanine-N7--methyltransferaseQuickGO ontologyBLASTP
948483948809327hypothetical proteinBLASTP
948920949846927glutaminaseQuickGO ontologyBLASTP
949958950488531hypothetical proteinBLASTP
9512089605229315virulence determinantQuickGO ontologyBLASTP
9607129618421131coproporphyrinogen III oxidaseQuickGO ontologyBLASTP
961835962263429hypothetical proteinBLASTP
962529962831303hypothetical proteinBLASTP
962816963370555hypothetical proteinBLASTP
963658964479822pyrroline-5-carboxylate reductaseQuickGO ontologyBLASTP
964612965220609hypothetical proteinBLASTP
9653309664541125hypothetical proteinBLASTP
9665639676781116hypothetical proteinBLASTP
967682968566885putative carbon-nitrogen hydrolaseQuickGO ontologyBLASTP
968746969168423Holliday junction resolvase-like proteinQuickGO ontologyBLASTP
969168969731564hypothetical proteinBLASTP
969847970806960glutathione synthetaseQuickGO ontologyBLASTP