Pre_GI Gene

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Host: NC_017154 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_017154:902739 Yersinia pestis D106004 chromosome, complete genome

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
9009949027421749putative siderophore biosynthesis protein IucCQuickGO ontologyBLASTP
902739903689951putative siderophore biosynthesis protein IucBQuickGO ontologyBLASTP
9036739047431071aerobactin synthetase subunit alphaQuickGO ontologyBLASTP
904836905444609aerobactin synthetase subunit alphaQuickGO ontologyBLASTP
9056959067021008hypothetical proteinBLASTP
907098907931834hypothetical proteinBLASTP
9083089096841377hypothetical proteinBLASTP
910246910989744quorum-sensing transcriptional regulatorQuickGO ontologyBLASTP
910970911497528N-acylhomoserine lactone synthase YtbIQuickGO ontologyBLASTP
913023913445423CAAX amino terminal protease family proteinQuickGO ontologyBLASTP
913896914291396putative lipoproteinQuickGO ontologyBLASTP
916567917067501hypothetical proteinBLASTP
9171169186541539hypothetical proteinBLASTP
9187719200181248hypothetical proteinBLASTP
920015920701687hypothetical proteinBLASTP
9207019218131113OmpA-family membrane proteinQuickGO ontologyBLASTP
921810922436627hypothetical proteinBLASTP
922440922931492hypothetical proteinBLASTP
9233199259612643putative ATPase subunit of ATP-dependent proteaseQuickGO ontologyBLASTP