Pre_GI Gene

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Host: NC_017154 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_017154:848500 Yersinia pestis D106004 chromosome, complete genome

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
8485008549586459HMWP2 nonribosomal peptide synthetaseQuickGO ontologyBLASTP
855166855945780insertion sequence IS100 ATP-binding proteinQuickGO ontologyBLASTP
8559458569671023transposase for insertion sequence IS100QuickGO ontologyBLASTP
8569818603943414nonribosomal peptide synthetasepolyketide synthaseQuickGO ontologyBLASTP
8605458626172073putative TonB-dependent outer membrane receptorQuickGO ontologyBLASTP
8630058642371233peptidase TQuickGO ontologyBLASTP
8643158658711557putative integral membrane efflux proteinQuickGO ontologyBLASTP
8665908684071818putative antigenic leucine-rich repeat proteinQuickGO ontologyBLASTP
868615869490876putative antigenic leucine-rich repeat proteinQuickGO ontologyBLASTP
8700868719331848antigenic leucine-rich repeat proteinQuickGO ontologyBLASTP
87203688315311118putative autotransporter proteinQuickGO ontologyBLASTP