Pre_GI Gene

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Host: NC_017154 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_017154:734875 Yersinia pestis D106004 chromosome, complete genome

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
734875735768894AraC-family regulatory proteinQuickGO ontologyBLASTP
735860736522663putative DedA-family membrane proteinQuickGO ontologyBLASTP
7367157379261212cystathionine beta-lyaseQuickGO ontologyBLASTP
7384057394421038MotATolQExbB proton channel family proteinQuickGO ontologyBLASTP
739446739877432ExbDTolR-family transport proteinQuickGO ontologyBLASTP
7399747414521479membrane proteinQuickGO ontologyBLASTP
741555742127573hypothetical proteinBLASTP
742111742581471hypothetical proteinBLASTP
742581743351771hypothetical proteinBLASTP
743335743916582hypothetical proteinBLASTP
744166745041876hypothetical proteinBLASTP
7450387463241287putative type II secretion proteinQuickGO ontologyBLASTP
7463367474631128hypothetical proteinBLASTP
747761748210450hypothetical proteinBLASTP
748225749079855hypothetical proteinBLASTP
749076749942867hypothetical proteinBLASTP
749994750416423hypothetical proteinBLASTP
750565751074510transposaseQuickGO ontologyBLASTP
751276751785510transposaseQuickGO ontologyBLASTP
7521387546182481outer membrane usher proteinQuickGO ontologyBLASTP