Pre_GI Gene

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Host: NC_017154 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_017154:671816 Yersinia pestis D106004 chromosome, complete genome

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
6718166739992184putative glycosyl hydrolaseQuickGO ontologyBLASTP
6740636754241362outer membrane efflux proteinQuickGO ontologyBLASTP
6755946774951902hypothetical proteinBLASTP
6774796785281050putative HlyD family secretion proteinQuickGO ontologyBLASTP
6798366810681233putative aminotransferaseQuickGO ontologyBLASTP
6810616825121452hypothetical proteinBLASTP
682525682962438hypothetical proteinBLASTP
683096683722627hypothetical proteinBLASTP
683738684118381putative translational inhibitor proteinQuickGO ontologyBLASTP
684403684807405putative translational inhibitor proteinQuickGO ontologyBLASTP
685022685324303hypothetical proteinBLASTP
685584686300717hypothetical proteinBLASTP
686480687394915LysR-family regulatory proteinQuickGO ontologyBLASTP
6894306908121383hypothetical proteinBLASTP
690821691291471hypothetical proteinBLASTP
691318691773456hypothetical proteinBLASTP
692058692396339hypothetical proteinBLASTP
6929146947521839RNA polymerase sigma factor RpoDQuickGO ontologyBLASTP