Pre_GI Gene

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Host: NC_017154 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_017154:520400 Yersinia pestis D106004 chromosome, complete genome

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
5194215204169964-hydroxythreonine-4-phosphate dehydrogenaseQuickGO ontologyBLASTP
5204005217041305survival protein SurA peptidyl-prolyl cis-trans isomeraseQuickGO ontologyBLASTP
5217725240242253organic solvent tolerance proteinQuickGO ontologyBLASTP
524299525132834Dna-J like membrane chaperone proteinQuickGO ontologyBLASTP
525430526050621ribosomal large subunit pseudouridine synthase AQuickGO ontologyBLASTP
527273527935663hypothetical proteinBLASTP
5283465293591014hypothetical proteinBLASTP
529370529930561hypothetical proteinBLASTP
5299305314411512hypothetical proteinBLASTP
531604532122519hypothetical proteinBLASTP
532196532639444hypothetical proteinBLASTP
5326725345161845hypothetical proteinBLASTP
534509535492984hypothetical proteinBLASTP
5355105380982589Clp ATPaseQuickGO ontologyBLASTP
5382025405502349hypothetical proteinBLASTP