Pre_GI Gene

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Host: NC_017154 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_017154:478000 Yersinia pestis D106004 chromosome, complete genome

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
4790404806411602bifunctional aspartokinasehomoserine dehydrogenase IQuickGO ontologyBLASTP
480647481498852bifunctional aspartokinasehomoserine dehydrogenase IQuickGO ontologyBLASTP
481501482430930homoserine kinaseQuickGO ontologyBLASTP
4824344837231290threonine synthaseQuickGO ontologyBLASTP
484540485316777hypothetical proteinBLASTP
485848486801954transaldolaseQuickGO ontologyBLASTP
487089487676588molybdenum cofactor biosynthesis proteinQuickGO ontologyBLASTP
4878044891921389putative transport proteinQuickGO ontologyBLASTP
4892624917092448hypothetical proteinBLASTP
491998492609612hypothetical proteinBLASTP
4929834948931911molecular chaperone DnaKQuickGO ontologyBLASTP
4950054961441140chaperone protein DnaJQuickGO ontologyBLASTP
496387497364978sodium-proton antiporterQuickGO ontologyBLASTP
497702498601900transcriptional activator protein NhaRQuickGO ontologyBLASTP
499461500348888bifunctional riboflavin kinaseFMN adenylyltransferaseQuickGO ontologyBLASTP