Pre_GI Gene

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Host: NC_017154 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_017154:3997810 Yersinia pestis D106004 chromosome, complete genome

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
399781040023004491insecticidal toxin complexQuickGO ontologyBLASTP
400235740044982142toxin subunitQuickGO ontologyBLASTP
400456740059491383toxin subunitQuickGO ontologyBLASTP
400599040084912502putative insecticidal toxinQuickGO ontologyBLASTP
40087274009539813lysR-family transcriptional regulatory proteinQuickGO ontologyBLASTP
40098544010765912LysR family transcriptional regulatorQuickGO ontologyBLASTP
40112794012214936putative HlyD family secretion proteinQuickGO ontologyBLASTP
401221640141711956hypothetical proteinBLASTP
401443840155711134succinate-semialdehyde dehydrogenaseQuickGO ontologyBLASTP
40155684015906339hypothetical proteinBLASTP
40161014016574474ribonucleaseQuickGO ontologyBLASTP
40169724017520549hypothetical proteinBLASTP
401770140190411341Putative modulator of DNA gyraseQuickGO ontologyBLASTP
40193264019934609hypothetical proteinBLASTP