Pre_GI Gene

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Host: NC_017154 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_017154:394401 Yersinia pestis D106004 chromosome, complete genome

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
3944013960441644putative acyl-CoA dehydrogenaseQuickGO ontologyBLASTP
396116396427312putative lipoproteinQuickGO ontologyBLASTP
396767397429663transposaseIS proteinQuickGO ontologyBLASTP
3974013985671167transposaseQuickGO ontologyBLASTP
3987014007642064hypothetical proteinBLASTP
4007614020771317hypothetical proteinBLASTP
4031014044261326modification methylaseQuickGO ontologyBLASTP
404476405198723hypothetical proteinBLASTP
4051704065431374hypothetical proteinBLASTP
4078154092031389hypothetical proteinBLASTP
4092004103541155hypothetical proteinBLASTP
4105004115461047M48 peptidase family proteinQuickGO ontologyBLASTP
4115574127531197hypothetical proteinBLASTP
413459413995537hypothetical proteinBLASTP
413997414872876putative transcriptional regulatorQuickGO ontologyBLASTP
414865415209345PTS system transporter subunit IIBQuickGO ontologyBLASTP
415302415622321PTS system transporter subunit IIBQuickGO ontologyBLASTP
4159634170451083PTS system transporter subunit IICQuickGO ontologyBLASTP
4175394199682430HPr family phosphocarrier proteinQuickGO ontologyBLASTP