Pre_GI Gene

Some Help

Host: NC_017154 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_017154:3898925 Yersinia pestis D106004 chromosome, complete genome

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
389892539015282604Clp ATPaseQuickGO ontologyBLASTP
39015253902322798hypothetical proteinBLASTP
39023193903005687hypothetical proteinBLASTP
390301139043991389hypothetical proteinBLASTP
390443139079643534hypothetical proteinBLASTP
39080893908871783hypothetical proteinBLASTP
39088683909401534hypothetical proteinBLASTP
390942339118252403putative Rhs accessory genetic elementQuickGO ontologyBLASTP
39118313912289459hypothetical proteinBLASTP
391228239151462865hypothetical proteinBLASTP
391517439165441371hypothetical proteinBLASTP
39165463917031486hypothetical proteinBLASTP
39176543918061408transcriptional regulatorQuickGO ontologyBLASTP
391842239206202199putative Rhs accessory genetic elementQuickGO ontologyBLASTP