Pre_GI Gene

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Host: NC_017154 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_017154:3576256 Yersinia pestis D106004 chromosome, complete genome

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
35762563577014759hypothetical proteinBLASTP
357734235786011260gamma-glutamyl phosphate reductaseQuickGO ontologyBLASTP
357861135797141104gamma-glutamyl kinaseQuickGO ontologyBLASTP
35798913580292402curlin genes regulatory proteinQuickGO ontologyBLASTP
358035235815991248hypothetical proteinBLASTP
35817263582184459xanthine phosphoribosyltransferaseQuickGO ontologyBLASTP
358311335847171605putative carbohydrate-binding proteinQuickGO ontologyBLASTP
35851773585962786LysR-family transcriptional regulatory proteinQuickGO ontologyBLASTP
358796335894231461aminoacyl-histidine dipeptidaseQuickGO ontologyBLASTP
358953735906071071DNA polymerase IVQuickGO ontologyBLASTP
35909513591898948hypothetical proteinBLASTP
35923823593377996putative thiamine biosynthesis lipoprotein apbEQuickGO ontologyBLASTP
359344535946681224Na-translocating NADH-quinone reductase subunit FQuickGO ontologyBLASTP
35946843595280597Na-translocating NADH-quinone reductase subunit EQuickGO ontologyBLASTP
35952873595916630NADH-ubiquinone oxidoreductaseQuickGO ontologyBLASTP
35959093596709801Na-translocating NADH-quinone reductase subunit CQuickGO ontologyBLASTP
359669935979401242Na-translocating NADH-quinone reductase subunit BQuickGO ontologyBLASTP
359794435992871344Na-translocating NADH-quinone reductase subunit AQuickGO ontologyBLASTP
35997833600523741hypothetical proteinBLASTP
36004883601261774hypothetical proteinBLASTP