Pre_GI Gene

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Host: NC_017154 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_017154:3444497 Yersinia pestis D106004 chromosome, complete genome

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
34444973445120624hypothetical proteinBLASTP
34451143445905792UDP-sugar hydrolaseQuickGO ontologyBLASTP
344643434476481215putative membrane efflux proteinQuickGO ontologyBLASTP
344788334495741692putative potassium antiporterQuickGO ontologyBLASTP
344967134509031233inosine-guanosine kinaseQuickGO ontologyBLASTP
34511793452030852O-antigen chain length determinantQuickGO ontologyBLASTP
345237834537511374phosphomannomutaseQuickGO ontologyBLASTP
34537563454499744glycosyl transferaseQuickGO ontologyBLASTP
345450234559081407mannose-1-phosphate guanylyltransferaseQuickGO ontologyBLASTP
34561443457109966nucleotide di-P-sugar epimerase or dehydrataseQuickGO ontologyBLASTP
34571153457708594GDP-mannose 46-dehydrataseQuickGO ontologyBLASTP
34577193458237519hypothetical proteinBLASTP
345825334592661014putative mannosyltransferaseQuickGO ontologyBLASTP
34595153460411897O-unit polymerase-like proteinQuickGO ontologyBLASTP
346073334618751143putative mannosyltransferaseQuickGO ontologyBLASTP
34622553462968714glycosyltransferaseQuickGO ontologyBLASTP