Pre_GI Gene

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Host: NC_017154 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_017154:3344273 Yersinia pestis D106004 chromosome, complete genome

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
334427333456221350putative two-component system sensor kinaseQuickGO ontologyBLASTP
33456483346331684putative two-component system response regulatorQuickGO ontologyBLASTP
334651933477241206putative HlyD family secretion proteinQuickGO ontologyBLASTP
334772833497642037ABC transporter ATP-binding proteinQuickGO ontologyBLASTP
335001933516651647putative pyridine nucleotide-disulfide oxidoreductaseQuickGO ontologyBLASTP
335172533531851461putative permeaseQuickGO ontologyBLASTP
335352233545291008peptidaseQuickGO ontologyBLASTP
335477533559561182putative aminotransferaseQuickGO ontologyBLASTP
335666433580821419membrane proteinQuickGO ontologyBLASTP
335831533598591545putative two-component sensor histidine kinaseQuickGO ontologyBLASTP
33598563360563708response regulatorQuickGO ontologyBLASTP
336094433621761233hypothetical proteinBLASTP
33624213363299879cysteine synthase BQuickGO ontologyBLASTP
336347033645611092sulfate transport ATP-binding proteinQuickGO ontologyBLASTP
33645513365426876sulfate transport system permease CysWQuickGO ontologyBLASTP
33654263366259834sulfate transport system permease CysTQuickGO ontologyBLASTP
336625933672961038thiosulfate-binding proteinQuickGO ontologyBLASTP