Pre_GI Gene

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Host: NC_017154 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_017154:331921 Yersinia pestis D106004 chromosome, complete genome

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
331921332235315hypothetical proteinBLASTP
3322493333971149alcohol dehydrogenaseQuickGO ontologyBLASTP
333464334288825rhamnulose-1-phosphate aldolaseQuickGO ontologyBLASTP
3343443355581215L-rhamnose isomeraseQuickGO ontologyBLASTP
3355553370121458rhamnulokinaseQuickGO ontologyBLASTP
337439338260822L-rhamnose operon regulatory proteinQuickGO ontologyBLASTP
338393339265873L-rhamnose operon transcriptional activatorQuickGO ontologyBLASTP
3394143404481035L-rhamnose-proton symporterQuickGO ontologyBLASTP
341304341729426hypothetical proteinBLASTP
3421563447112556enhancing factorQuickGO ontologyBLASTP
34514534522076tRNA-PheQuickGO ontologyBLASTP
345365345940576putative TetR-family regulatory proteinQuickGO ontologyBLASTP
3463603483752016oxidoreductase Fe-S subunitQuickGO ontologyBLASTP
3483983489555584Fe-4S ferredoxinQuickGO ontologyBLASTP
3489783511252148formate dehydrogenase HQuickGO ontologyBLASTP
3511873529741788thioldisulfide interchange proteinQuickGO ontologyBLASTP
3534933547941302anaerobic C4-dicarboxylate transporterQuickGO ontologyBLASTP