Pre_GI Gene

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Host: NC_017154 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_017154:3188795 Yersinia pestis D106004 chromosome, complete genome

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
318879531911762382putative beta-glucosidaseQuickGO ontologyBLASTP
31913353191865531hypothetical proteinBLASTP
319185831940652208hypothetical proteinBLASTP
319451731957251209transposaseQuickGO ontologyBLASTP
31958043196112309hypothetical proteinBLASTP
31961273196708582hypothetical proteinBLASTP
319724331991591917putative autotransporter proteinQuickGO ontologyBLASTP
32005213201093573hypothetical proteinBLASTP
32011053201506402hypothetical proteinBLASTP
32017393202140402hypothetical proteinBLASTP
32024083202989582hypothetical proteinBLASTP
320412032055111392hypothetical proteinBLASTP
320568632068941209transposaseQuickGO ontologyBLASTP
320703432082901257PTS system ascorbate-specific transporter subunit IICQuickGO ontologyBLASTP
32084073208955549hypothetical proteinBLASTP
32091773209755579phosphodiesteraseQuickGO ontologyBLASTP
32099523210644693EAL domain-containing proteinQuickGO ontologyBLASTP
32109983211906909hypothetical proteinBLASTP
32120303212827798histidine transport ATP-binding protein HisPQuickGO ontologyBLASTP