Pre_GI Gene

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Host: NC_017154 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_017154:3139614 Yersinia pestis D106004 chromosome, complete genome

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
31396143140114501NADH dehydrogenase subunit alphaQuickGO ontologyBLASTP
31402163140893678NADH dehydrogenase subunit betaQuickGO ontologyBLASTP
314103431428301797NADH dehydrogenase I subunit CDQuickGO ontologyBLASTP
31428333143396564ATP synthase subunit EQuickGO ontologyBLASTP
314339331447781386NADH dehydrogenase I subunit FQuickGO ontologyBLASTP
314486531476092745NADH dehydrogenase subunit gammaQuickGO ontologyBLASTP
31476063148583978NADH dehydrogenase subunit HQuickGO ontologyBLASTP
31485983149140543NADH dehydrogenase subunit IQuickGO ontologyBLASTP
31491533149698546NADH dehydrogenase subunit JQuickGO ontologyBLASTP
31496953149997303NADH dehydrogenase kappa subunitQuickGO ontologyBLASTP
314999431518381845NADH dehydrogenase subunit LQuickGO ontologyBLASTP
315187831534101533NADH dehydrogenase subunit MQuickGO ontologyBLASTP
315341731548801464NADH dehydrogenase subunit NQuickGO ontologyBLASTP
315511631563061191hypothetical proteinBLASTP
31566583157125468hypothetical proteinBLASTP
31572033157739537putative thermosensitive gluconokinaseQuickGO ontologyBLASTP
31577883158552765gluconate 5-dehydrogenaseQuickGO ontologyBLASTP
315931131605941284putative lipoproteinQuickGO ontologyBLASTP
31610633162055993putative LacI-family transcriptional regulatorQuickGO ontologyBLASTP