Pre_GI Gene

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Host: NC_017154 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_017154:3094000 Yersinia pestis D106004 chromosome, complete genome

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
30940223094612591LuxR family transcriptional regulatorQuickGO ontologyBLASTP
309506230960991038hypothetical proteinBLASTP
309735230991421791ABC transporter ATP-binding proteinQuickGO ontologyBLASTP
30992073099509303hypothetical proteinBLASTP
30997123100527816hypothetical proteinBLASTP
310053731015951059myo-inositol catabolism protein iolBQuickGO ontologyBLASTP
310161031034871878putative carbohydrate kinaseQuickGO ontologyBLASTP
310361231047451134hypothetical proteinBLASTP
310476931057971029sugar transport system permeaseQuickGO ontologyBLASTP
310580931073561548D-ribose high-affinity ABC transporter ATP-binding proteinQuickGO ontologyBLASTP
31074053108334930putative sugar-binding periplasmic proteinQuickGO ontologyBLASTP
31084603108903444myo-inositol 2-dehydrogenaseQuickGO ontologyBLASTP
31089363109445510hypothetical proteinBLASTP
310973931116851947putative thiamine pyrophosphate-dependent proteinQuickGO ontologyBLASTP
311169931132251527putative aldehyde dehydrogenaseQuickGO ontologyBLASTP
31135313114385855hypothetical proteinBLASTP
31150193115567549hypothetical proteinBLASTP
311597431219525979membrane proteinQuickGO ontologyBLASTP