Pre_GI Gene

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Host: NC_017154 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_017154:2999841 Yersinia pestis D106004 chromosome, complete genome

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
299984130014841644phosphoglucomutaseQuickGO ontologyBLASTP
30015573002084528putative negative regulator of replication initiationQuickGO ontologyBLASTP
30032423004003762hypothetical proteinBLASTP
30040553004885831cel operon repressorQuickGO ontologyBLASTP
30049343005281348PTS system cellobiose-specific transporter subunit IIAQuickGO ontologyBLASTP
300544830068091362PTS system cellobiose-specific transporter subunit IICQuickGO ontologyBLASTP
30068203007137318PTS system cellobiose-specific transporter subunit IIBQuickGO ontologyBLASTP
30081963008558363membrane proteinQuickGO ontologyBLASTP
30085743008978405camphor resistance protein CrcBQuickGO ontologyBLASTP
300907630102511176putative potassium channel proteinQuickGO ontologyBLASTP
30108693011198330hypothetical proteinBLASTP
301136730124251059putative nickel transport proteinQuickGO ontologyBLASTP
30125743013566993putative urea transporterQuickGO ontologyBLASTP
30138913014724834hypothetical proteinBLASTP
30147213015383663urease accessory proteinQuickGO ontologyBLASTP
30155103016196687urease accessory proteinQuickGO ontologyBLASTP
30162183016913696urease accessory proteinQuickGO ontologyBLASTP
301720930189271719urease alpha subunitQuickGO ontologyBLASTP
30190173019493477urease urea amidohydrolase beta subunitQuickGO ontologyBLASTP
30195043019806303urease subunit gammaQuickGO ontologyBLASTP