Pre_GI Gene

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Host: NC_017154 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_017154:2901300 Yersinia pestis D106004 chromosome, complete genome

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
29013002902289990DNA-binding proteinQuickGO ontologyBLASTP
29023272902797471fimbrial biogenesis proteinQuickGO ontologyBLASTP
290323129044271197hypothetical proteinBLASTP
29046892905117429nucleoside diphosphate kinaseQuickGO ontologyBLASTP
290544429078642421hypothetical proteinBLASTP
290881129129564146putative autotransporter proteinQuickGO ontologyBLASTP
291351429166723159hypothetical proteinBLASTP
29166382916958321hypothetical proteinBLASTP
29172962918249954hypothetical proteinBLASTP
291832829196261299aminopeptidase BQuickGO ontologyBLASTP
29199962920331336adrenodoxin family ferredoxinQuickGO ontologyBLASTP
292033429222861953chaperone protein HscAQuickGO ontologyBLASTP
29225292923053525co-chaperone HscBQuickGO ontologyBLASTP
29231642923487324iron-sulfur cluster assembly proteinQuickGO ontologyBLASTP
29237572924143387NifU family proteinQuickGO ontologyBLASTP