Pre_GI Gene

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Host: NC_017154 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_017154:2876545 Yersinia pestis D106004 chromosome, complete genome

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
287654528778641320proteaseQuickGO ontologyBLASTP
28785002879390891putative diacylglycerol kinaseQuickGO ontologyBLASTP
28796772880186510hypothetical proteinBLASTP
28805592881305747hypothetical proteinBLASTP
28813672882167801phosphomethylpyrimidine kinaseQuickGO ontologyBLASTP
28826892883156468membrane proteinQuickGO ontologyBLASTP
288350528847131209transposase for the IS285 insertion elementQuickGO ontologyBLASTP
28848042885439636hypothetical proteinBLASTP
28854362885831396hypothetical proteinBLASTP
28868112887209399hypothetical proteinBLASTP
28872332887712480hypothetical proteinBLASTP
28878722888381510transposaseQuickGO ontologyBLASTP
288870528902821578bifunctional GMP synthaseglutamine amidotransferase proteinQuickGO ontologyBLASTP
289046228920091548inositol-5-monophosphate dehydrogenaseQuickGO ontologyBLASTP
289209528934741380exodeoxyribonuclease VII large subunitQuickGO ontologyBLASTP
28938482894804957hypothetical proteinBLASTP
289515128966381488GTP-binding protein EngAQuickGO ontologyBLASTP
289678628979671182putative lipoproteinQuickGO ontologyBLASTP
28979792898614636hypothetical proteinBLASTP