Pre_GI Gene

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Host: NC_017154 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_017154:2804000 Yersinia pestis D106004 chromosome, complete genome

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
280425228053371086tartrate dehydrogenaseQuickGO ontologyBLASTP
28054402806381942LysR family transcriptional regulatorQuickGO ontologyBLASTP
280662828076321005putative LacI-family transcriptional regulatorQuickGO ontologyBLASTP
28077652808757993putative sugar transport system permeaseQuickGO ontologyBLASTP
280875428102441491putative sugar transport system ATP-binding proteinQuickGO ontologyBLASTP
28102842811201918sugar binding proteinQuickGO ontologyBLASTP
281137628126021227putative zinc-binding dehydrogenaseQuickGO ontologyBLASTP
28131852813853669hypothetical proteinBLASTP
28140492814591543hypothetical proteinBLASTP
28148292815767939hypothetical proteinBLASTP
28160832816607525outer membrane protein XQuickGO ontologyBLASTP
28170182817899882integral membrane proteinQuickGO ontologyBLASTP
28179152818412498hypothetical proteinBLASTP
28184352819211777trans-aconitate 2-methyltransferaseQuickGO ontologyBLASTP
28194682819971504DNA protection proteinQuickGO ontologyBLASTP
282029128214181128hypothetical proteinBLASTP