Pre_GI Gene

Some Help

Host: NC_017154 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_017154:2774955 Yersinia pestis D106004 chromosome, complete genome

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
277495527760101056hypothetical proteinBLASTP
27761572776981825sugar ABC transporter permeaseQuickGO ontologyBLASTP
27769822777857876sugar ABC transporter permeaseQuickGO ontologyBLASTP
277796627792521287putative solute-binding proteinQuickGO ontologyBLASTP
277952427805641041LacI family transcriptional repressorQuickGO ontologyBLASTP
278058127819691389phosphomannomutaseQuickGO ontologyBLASTP
278206927831481080putative mannitol transport ATP-binding proteinQuickGO ontologyBLASTP
27834132783865453hypothetical proteinBLASTP
27842162784608393hypothetical proteinBLASTP
27858912786484594hypothetical proteinBLASTP
27864902787104615hypothetical proteinBLASTP
27870762787924849hypothetical proteinBLASTP
27890842789593510hypothetical proteinBLASTP
278959527971907596adhesinQuickGO ontologyBLASTP
279734627990341689putative hemolysin activator proteinQuickGO ontologyBLASTP