Pre_GI Gene

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Host: NC_017154 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_017154:2430093 Yersinia pestis D106004 chromosome, complete genome

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
24300932430644552nitroreductaseQuickGO ontologyBLASTP
24309442431915972selenide water dikinaseQuickGO ontologyBLASTP
243197724339021926DNA topoisomerase IIIQuickGO ontologyBLASTP
24342022434588387putative pyrophosphohydrolaseQuickGO ontologyBLASTP
24346862435492807exodeoxyribonuclease IIIQuickGO ontologyBLASTP
24363022437162861LysR-family transcriptional regulatory proteinQuickGO ontologyBLASTP
2437670243775485tRNA-TyrQuickGO ontologyBLASTP
243803424392421209transposaseQuickGO ontologyBLASTP
24392052440074870hypothetical proteinBLASTP
24401582440622465hypothetical proteinBLASTP
244195624429721017response regulatorQuickGO ontologyBLASTP
244327924446251347putative nucleotide sugar dehydrogenaseQuickGO ontologyBLASTP
24450602445458399DNA-binding protein HnsQuickGO ontologyBLASTP
24462982446798501thymidine kinaseQuickGO ontologyBLASTP
24471672447829663transposaseIS proteinQuickGO ontologyBLASTP
244794524489671023transposase for insertion sequence IS100QuickGO ontologyBLASTP
244950724514771971aldehyde-alcohol dehydrogenaseQuickGO ontologyBLASTP
24514772452181705aldehyde-alcohol dehydrogenaseQuickGO ontologyBLASTP
24529882453632645hypothetical proteinBLASTP
245453024561071578oligopeptide ABC transporter periplasmic oligopeptide-binding proteinQuickGO ontologyBLASTP