Pre_GI Gene

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Host: NC_017154 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_017154:2306421 Yersinia pestis D106004 chromosome, complete genome

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
23064212306984564putative lipoproteinQuickGO ontologyBLASTP
230737923085841206hypothetical proteinBLASTP
23090702309462393ribosomal-protein-alanine acetyltransferaseQuickGO ontologyBLASTP
230947023110801611putative oxidoreductaseQuickGO ontologyBLASTP
231134723128821536hypothetical proteinBLASTP
23133702313723354hemolysin activator proteinQuickGO ontologyBLASTP
231373523150301296hemolysin activator proteinQuickGO ontologyBLASTP
231531523197904476hemolysinQuickGO ontologyBLASTP
232002123217511731arginyl-tRNA synthetaseQuickGO ontologyBLASTP
23223502322925576hypothetical proteinBLASTP
23231572323921765putative copper homeostasis proteinQuickGO ontologyBLASTP