Pre_GI Gene

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Host: NC_017154 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_017154:2258228 Yersinia pestis D106004 chromosome, complete genome

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
225822822603902163hypothetical proteinBLASTP
226096822630792112hypothetical proteinBLASTP
22633262263736411sugar-phosphate isomeraseQuickGO ontologyBLASTP
22640982264757660hypothetical proteinBLASTP
22649452265541597dehydrogenaseQuickGO ontologyBLASTP
22658822266832951hypothetical proteinBLASTP
22668192267751933hypothetical proteinBLASTP
22677572268662906hypothetical proteinBLASTP
226945322705261074hypothetical proteinBLASTP
22707392271209471hypothetical proteinBLASTP
22712642271686423putative decarboxylaseQuickGO ontologyBLASTP
227196322733481386two-component system sensor proteinQuickGO ontologyBLASTP
22733602274052693transcriptional activatorQuickGO ontologyBLASTP
227431722754081092hypothetical proteinBLASTP
22755992276264666hypothetical proteinBLASTP
22762792276974696hypothetical proteinBLASTP
22771832278025843hypothetical proteinBLASTP