Pre_GI Gene

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Host: NC_017154 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_017154:2137500 Yersinia pestis D106004 chromosome, complete genome

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
21375132138094582hypothetical proteinBLASTP
21386082139042435yp42QuickGO ontologyBLASTP
214040821424292022pesticinyersiniabactin receptor proteinQuickGO ontologyBLASTP
214256021441371578yersiniabactin siderophore biosynthetic proteinQuickGO ontologyBLASTP
21441412144944804yersiniabactin biosynthetic protein YbtTQuickGO ontologyBLASTP
214494121460411101yersiniabactin biosynthetic protein YbtUQuickGO ontologyBLASTP
214603821555299492yersiniabactin biosynthetic proteinQuickGO ontologyBLASTP
215561721617246108yersiniabactin biosynthetic proteinQuickGO ontologyBLASTP
21619152162874960transcriptional regulator YbtAQuickGO ontologyBLASTP
216313121648431713lipoprotein inner membrane ABC-transporterQuickGO ontologyBLASTP
216483021666321803inner membrane ABC-transporter YbtQQuickGO ontologyBLASTP
216662521679051281putative signal transducerQuickGO ontologyBLASTP
216793321692371305anthranilate synthase component IQuickGO ontologyBLASTP
216943121706931263integraseQuickGO ontologyBLASTP
2170855217093076tRNA-AsnQuickGO ontologyBLASTP
21712332171973741pili assembly chaperoneQuickGO ontologyBLASTP
21719702172278309hypothetical proteinBLASTP
21723112173246936hypothetical proteinBLASTP
217333421758982565fimbrial usher proteinQuickGO ontologyBLASTP
21759742176618645pili assembly chaperoneQuickGO ontologyBLASTP