Pre_GI Gene

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Host: NC_017154 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_017154:2100587 Yersinia pestis D106004 chromosome, complete genome

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
21005872101414828hypothetical proteinBLASTP
210144421025741131hypothetical proteinBLASTP
210258521038891305hypothetical proteinBLASTP
21039752104574600TrpR binding protein WrbAQuickGO ontologyBLASTP
210496821061461179hypothetical proteinBLASTP
210627221076961425D-serineD-alanineglycine transporterQuickGO ontologyBLASTP
2108049210812476tRNA-LysQuickGO ontologyBLASTP
21088112109362552attachment invasion locus proteinQuickGO ontologyBLASTP
21099842110328345hypothetical proteinBLASTP
21113402111996657response regulatorQuickGO ontologyBLASTP
211205521138211767excinuclease ABC subunit CQuickGO ontologyBLASTP
21138802114428549CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferaseQuickGO ontologyBLASTP
2114573211464876tRNA-GlyQuickGO ontology
2114701211477474tRNA-CysQuickGO ontologyBLASTP
2114785211487086tRNA-LeuQuickGO ontologyBLASTP
21175722117916345hypothetical proteinBLASTP
21181362118984849transposaseQuickGO ontologyBLASTP