Pre_GI Gene

Some Help

Host: NC_017154 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_017154:1707500 Yersinia pestis D106004 chromosome, complete genome

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
170806817096391572ABC transporter ATP-binding proteinQuickGO ontologyBLASTP
17098671710520654hypothetical proteinBLASTP
171056417117721209transposaseQuickGO ontologyBLASTP
17119081712678771molybdopterin biosynthesis proteinQuickGO ontologyBLASTP
171268017139541275molybdopterin biosynthesis proteinQuickGO ontologyBLASTP
171448917157991311putative heme-binding proteinQuickGO ontologyBLASTP
17158091716477669ABC transporter ATP-binding proteinQuickGO ontologyBLASTP
171647917177411263hypothetical proteinBLASTP
171774317200612319hypothetical proteinBLASTP
17206561721498843putative esteraseQuickGO ontologyBLASTP
172151917226581140alcohol dehydrogenaseQuickGO ontologyBLASTP
17229321723801870putative LysR-family transcriptional regulatory proteinQuickGO ontologyBLASTP
172393717250881152hypothetical proteinBLASTP
17252721725934663GTP cyclohydrolase IQuickGO ontologyBLASTP
172598917271551167hypothetical proteinBLASTP
17279031728895993galactose-binding proteinQuickGO ontologyBLASTP
172912517306451521galactoside transport ATP-binding proteinQuickGO ontologyBLASTP