Pre_GI Gene

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Host: NC_017154 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_017154:1454704 Yersinia pestis D106004 chromosome, complete genome

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
145470414558971194mannonate dehydrataseQuickGO ontologyBLASTP
14560371456651615elongation factor PQuickGO ontologyBLASTP
145671314579571245putative tryptophan-specific transport proteinQuickGO ontologyBLASTP
14586551459470816putative short chain oxidoreductaseQuickGO ontologyBLASTP
14594811460431951D-isomer specific 2-hydroxyacid dehydrogenase family proteinQuickGO ontologyBLASTP
146044314615851143hypothetical proteinBLASTP
146193714634331497putative aldehyde dehydrogenaseQuickGO ontologyBLASTP
146343714649901554putative carbohydrate kinaseQuickGO ontologyBLASTP
14650101465720711putative ribose 5-phosphate isomeraseQuickGO ontologyBLASTP
146585214669401089putative periplasmic carbohydrate-binding transport proteinQuickGO ontologyBLASTP
146704914686231575putative ABC transport ATP-binding subunitQuickGO ontologyBLASTP
14686591469657999putative ABC transport integral membrane subunitQuickGO ontologyBLASTP
14697231470226504Mut family proteinQuickGO ontologyBLASTP
147048814716211134hypothetical proteinBLASTP
147161814725569391-phosphofructokinaseQuickGO ontologyBLASTP
147257114742711701PTS system fructose-specific transporter subunit IIBCQuickGO ontologyBLASTP
14745961475240645putative regulatory proteinQuickGO ontologyBLASTP
14752371475725489hypothetical proteinBLASTP